# Welcome to the frontier of AI in medicine
Sean Davis, MD, PhD
October 12, 2026

## Next July

<span class="lede">It is your first week as an intern. An AI scribe has
drafted your note. A patient asks whether ChatGPT got her diagnosis
right.</span>

<span class="lede">Nobody can teach you in advance where these tools
help and where they fail. The tools change every few months.</span>

<span class="lede">**So how do you get good at this?** That is what
today is about.</span>

## The field is moving faster than anyone can read

<img src="images/pubmed-ai-ml.svg"
data-fig-alt="Line chart of PubMed papers per year matching artificial intelligence or machine learning, 1990 to 2025. The line is nearly flat below 10,000 until 2016, then rises steeply to 101,781 papers in 2025. Points mark 2012 and 2022."
height="640" />

<span class="illustrative">Redrawn from PubMed counts, retrieved October
11, 2026</span>

<div class="aside">

Source: ([National Library of Medicine, 2026](#ref-pubmedcounts2026)).

</div>

## About me

<div class="columns">

<div class="column center-col" width="24%">

<img src="images/sean-davis-headshot.jpg" class="photo"
data-fig-alt="Portrait photograph of Sean Davis." height="340" />

</div>

<div class="column" width="76%">

<div class="timeline six">

<div class="era">

<span class="when">Princeton</span>

<span class="what">Engineering</span>

<span class="how">Mechanical and aerospace</span>

</div>

<div class="era">

<span class="when">Pittsburgh</span>

<span class="what">MD, PhD</span>

<span class="how">PhD in human genetics</span>

</div>

<div class="era">

<span class="when">Seattle</span>

<span class="what">Pediatrics</span>

<span class="how">Residency, University of Washington</span>

</div>

<div class="era">

<span class="when">Baltimore</span>

<span class="what">Pediatric oncology</span>

<span class="how">Johns Hopkins and NCI fellowship</span>

</div>

<div class="era">

<span class="when">NIH</span>

<span class="what">Genomics and data</span>

<span class="how">2005 to 2020: NHGRI, then the National Cancer
Institute</span>

</div>

<div class="era now">

<span class="when">CU Anschutz</span>

<span class="what">Informatics and AI</span>

<span class="how">Professor of Medicine and Biomedical
Informatics</span>

</div>

</div>

<div style="margin-top: 1.4em;">

- I use AI **every day**, for code, writing, and learning new fields
- I am **not** selling AI. Expect me to show you its failures too

</div>

</div>

</div>

## The one idea of this course

<span class="lede">**It is your job to learn where AI helps your
work.**</span>

Nobody can tell you in advance. You find out by trying, often, on things
that matter to you. You learn where AI fails the same way.

This course gives you **a framework, a routine, and people to try things
with.** Most of your learning will be your own, done with AI.

## <span class="year">Part 1</span> How you learn: what the evidence says

<span class="lede">Last year’s class heard three classic theories of
adult learning here. Some of that does not hold up. Here is what
does.</span>

<div class="notes">

Part one.

A confession. Last year I opened the course with three classic theories
of adult learning: Knowles’ andragogy, Mezirow’s transformative
learning, and self-directed learning. I showed a table contrasting how
children learn with how adults learn.

When I went back to the research for this year, much of that table did
not hold up. So I am going to show you what I said, what the evidence
actually supports, and what that means for how you spend these four
weeks.

This is also a small example of the course itself: something I believed,
checked against the evidence, and changed.

</div>

## What I taught last year’s class

<div class="columns">

<div class="column" width="50%">

<div class="panel warm">

<span class="ptitle">The old story: andragogy, Knowles’ theory of how
adults learn</span>

- Adults are **self-directed**; children depend on the teacher
- Adults are driven by **internal** motivation; children by grades
- Adults learn from **problems**; children from subjects
- So adults need a **different kind of teaching** from children

</div>

</div>

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">What the research supports</span>

- The child versus adult split is **artificial**. Learning is a
  continuum across life ([Taylor & Hamdy, 2013](#ref-pmid:24004029))
- After decades, studies of andragogy are **inconclusive** ([Rachal,
  2002](#ref-doi:10.1177/0741713602052003004))
- One essay argues medical students’ internal and external motivations
  are **mixed together** and depend on context ([Misch,
  2002](#ref-pmid:12075147))
- Still useful: **experience** and **relevance** matter

</div>

</div>

</div>

<div class="notes">

On the left is the core of what I taught last year. Malcolm Knowles, in
the 1970s and 80s, described adult learners as self-directed, internally
motivated, and problem-centred, and contrasted that with children.

On the right is what the research supports.

First, a major medical education guide, AMEE Guide 83, says the split
between adult and child learning “now seems to be artificial”. Most of
the principles apply to children too. It is better thought of as a
continuum.

Second, Knowles himself called these assumptions, not a tested theory. A
2002 review of the research on andragogy found it inconclusive after
three decades, partly because nobody agreed on what to measure.

Third, the claim that adults are driven from within. A 2002 essay on
medical students argues that internal and external motivation are mixed
together and change with context. You want to learn medicine and you
want to match. Both are real.

What survives: your experience is a resource, and relevance matters.
Those are good design rules. They just do not make adults learn in a
different way from children.

(Mezirow’s transformative learning describes how people change their
frame of reference. It is a description more than a tested model, so I
have dropped it from the slides.)

</div>

## Feeling that you learned is not the same as learning

<div class="columns">

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">Physics students, randomised</span>

Same content, two kinds of class. Students in **active** classes
**learned more**, but **felt** they had learned **less** than students
in polished lectures. ([Deslauriers et al., 2019](#ref-pmid:31484770))

</div>

</div>

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">Physicians judging themselves</span>

A systematic review compared physicians’ self-ratings with observed
competence. In **13 of 20** comparisons there was little, no, or an
**inverse** relationship. ([Davis et al., 2006](#ref-pmid:16954489))

</div>

</div>

</div>

<div class="fragment" style="margin-top: 1.2em;">

**Why it matters for AI:** a chatbot gives smooth, confident answers.
Reading them **feels** like understanding. That feeling does not tell
you whether you learned.

</div>

<div class="notes">

This is, I think, the most important finding for this course.

On the left: a Harvard physics study. Students were randomly assigned to
active classes or to lectures by experienced, highly rated lecturers,
with the same content and handouts. The active-class students learned
more on the test. But they rated their own learning lower. The effort
felt like failure.

On the right: a JAMA systematic review of physicians. When they compared
physicians’ ratings of themselves with outside measures of competence,
most comparisons showed little, no, or even an inverse relationship.
Self-ratings were least accurate among the least skilled physicians and
among the most confident.

\[Click\] Why this matters for AI. A chatbot gives you a fluent,
confident, well-organised answer. Reading it feels like understanding.
But feeling that you learned and actually learning are different things,
and you, like everyone, are not good at telling them apart from the
inside. So you need ways of checking that do not depend on how it feels.

</div>

## What works, rated by usefulness

<div class="columns">

<div class="column" width="34%">

<div class="panel">

<span class="ptitle">High usefulness</span>

- **Testing yourself**: recall it, do not reread it
- **Spacing it out**: come back over days and weeks

</div>

</div>

<div class="column" width="33%">

<div class="panel">

<span class="ptitle">Moderate usefulness</span>

- **Explaining why** it is true
- **Explaining it to yourself** step by step
- **Mixing** different kinds of problems

</div>

</div>

<div class="column" width="33%">

<div class="panel warm">

<span class="ptitle">Low usefulness</span>

- **Rereading**
- **Highlighting**
- **Summarising**

Rereading and highlighting are what students use most

</div>

</div>

</div>

You already know this from Anki and question banks. A medical education
review argues for **frequent, spaced tests with feedback** ([Larsen et
al., 2008](#ref-pmid:18823514)).

<div class="aside">

Ratings from a review of ten study techniques ([Dunlosky et al.,
2013](#ref-pmid:26173288)). Testing effect: ([Roediger & Karpicke,
2006](#ref-pmid:16507066)). Spacing: ([Cepeda et al.,
2006](#ref-pmid:16719566)).

</div>

<div class="notes">

In 2013, five cognitive psychologists rated ten common study techniques
by how useful they are, based on whether the benefits hold across ages,
materials, and kinds of test.

Most of you already do this: Anki and question banks are testing and
spacing. So I will be quick, and the point is the AI link coming up.

Two came out on top. Testing yourself: pulling the answer out of your
memory rather than reading it again. And spacing: coming back to
material over days and weeks rather than cramming.

In the middle: explaining why something is true, explaining it to
yourself step by step, and mixing different kinds of problems together.

At the bottom: rereading, highlighting, summarising. Rereading and
highlighting are the ones students report using most, because they feel
productive.

A 2008 review in Medical Education argued for exactly this in medicine:
test often, space it out, give feedback.

You will see these ideas in the course design: a weekly journal where
you recall what you tried, small groups where you explain it out loud,
and a routine that brings you back every week.

</div>

## What keeps you going

<div class="columns">

<div class="column" width="55%">

**Self-determination theory**: people stay motivated when three needs
are met ([Ryan & Deci, 2000](#ref-pmid:11392867); [Ten Cate et al.,
2011](#ref-pmid:22225433)).

- **Autonomy**: you have real choices
- **Competence**: you can see yourself getting better
- **Relatedness**: you learn alongside other people

In 383 medical students, motivation from **within** went with **deeper
study** and, through it, **better grades** ([Kusurkar et al.,
2012](#ref-pmid:22354335)).

</div>

<div class="column" width="45%">

<div class="panel">

<span class="ptitle">How the course uses it</span>

- **Autonomy**: you choose your sessions, your topics, and what you
  learn with AI
- **Competence**: you try things weekly and write down what you caught
- **Relatedness**: Friday small groups, and an unofficial Discord

</div>

</div>

</div>

<div class="notes">

So if “adults are internally motivated” is too simple, what do we know
about motivation?

Self-determination theory, from Deci and Ryan, is one of the best-tested
theories of motivation in psychology, and there is an AMEE guide
applying it to medical education. It says people stay motivated when
three needs are met: autonomy, real choice; competence, seeing yourself
improve; and relatedness, doing it with other people.

It also distinguishes motivation that comes from within, because you
value the thing, from motivation that is controlled from outside, by
grades or pressure. A Dutch study of 383 medical students found that
motivation from within went with deeper study strategies and more
effort, and through those, better grades.

On the right is how this course is built around it. The course is
ungraded on purpose. You choose what to attend and what to learn. You
try things and record what you caught. And you do it with other people
on Fridays.

</div>

## Self-directed, but not unguided

<div class="columns">

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">Self-directed learning helps knowledge</span>

Across 59 studies in health professions, self-directed learning gave a
**moderate gain in knowledge**, with no clear effect on skills. It
worked better when learners **chose their own resources**, and for
**more advanced** learners. ([Murad et al., 2010](#ref-pmid:20946476))

</div>

</div>

<div class="column" width="50%">

<div class="panel warm">

<span class="ptitle">Beginners need structure</span>

A widely cited review argues that when people are new to a field,
learning with **little guidance** works **less well** than guided
practice. ([Kirschner et al., 2006](#ref-doi:10.1207/s15326985ep4102_1))

Most of you are new to AI. So the course gives you a framework and a
weekly routine.

</div>

</div>

</div>

<div class="notes">

Self-directed learning is the third theory I taught last year. The
evidence here is more encouraging, with a catch.

A Mayo Clinic systematic review of 59 studies in health professions
education found that self-directed learning gave a moderate improvement
in knowledge compared with traditional teaching, though no clear effect
on skills. It worked better when learners helped choose the resources,
and advanced learners benefited more.

You are advanced learners in medicine. In AI, most of you are beginners.
A widely cited review argues that for beginners, discovery with little
guidance works less well than guided practice, because a novice does not
yet know what to look for. That claim is debated, but it fits what I
have seen in this course.

So that is the design: you direct your own learning, inside a framework,
with a weekly routine and people to check in with.

</div>

## AI can help you learn, or do the learning for you

<div class="columns">

<div class="column" width="54%">

**About 1,000 high school students**, randomised, practising maths
([Bastani et al., 2025](#ref-pmid:40560616)):

<div class="stats">

<div class="stat">

<span class="num">+48%</span>

<span class="lab">practice grades with a ChatGPT-like assistant</span>

</div>

<div class="stat">

<span class="num">−17%</span>

<span class="lab">exam grades once it was taken away, compared with no
AI</span>

</div>

<div class="stat">

<span class="num">Largely avoided</span>

<span class="lab">with a tutor version that gave hints, not
answers</span>

</div>

</div>

Students used the plain version **as a crutch**.

</div>

<div class="column" width="46%">

<div class="panel warm">

<span class="ptitle">The same thing in clinicians?</span>

Endoscopists in Poland began using AI to spot polyps. In their
colonoscopies **without** AI, the adenoma detection rate fell from
**28.4% to 22.4%**. ([Budzyń et al., 2025](#ref-pmid:40816301))

One observational study, so not proof. But it is the risk to watch.

</div>

</div>

</div>

<div class="notes">

This is the evidence behind a line from last year’s slides: use AI in
support of your learning, not to replace it.

A 2025 field experiment with nearly a thousand high school students
practising maths. One group had a plain ChatGPT-style assistant; one had
a tutor version designed to give hints rather than answers; one had
nothing. With the plain assistant, practice grades went up 48 percent.
Then, on the exam without AI, those students did 17 percent worse than
students who never had it. They had used it as a crutch. The tutor
version largely avoided that harm.

On the right, the same worry in clinicians. Endoscopists at four Polish
centres started using AI to detect polyps. When they did colonoscopies
without the AI, their adenoma detection rate fell from 28 to 22 percent.
That is one observational study, and there are other explanations, but
it is exactly the risk: the skill you hand to the machine is the skill
you stop practising.

The lesson is not “avoid AI”. It is “use it in a way that makes you do
the thinking”.

</div>

## Learning with AI: six habits from the evidence

1.  **Tell the AI what you want to learn**, why, and what you already
    know.
2.  **Try first, then ask.** Write your answer, then compare it with the
    AI’s
3.  **Ask it to quiz you**, not to explain again. Testing beats
    rereading
4.  **Explain it back** in your own words, and ask the AI what you got
    wrong
5.  **Come back to it** later in the week. Spacing beats cramming
6.  **Write down what you caught.** Your sense of “I get it” is not
    enough

<div class="fragment" style="margin-top: 1em;">

This is the main work of the course: **Learn it with AI**, 2 to 4 hours
a week, on something you care about.

</div>

<div class="notes">

Putting it together, six habits, each tied to the research we just saw.

One: tell the AI what you want to learn, why, and what you already know.
You are setting the goal, not the machine, and it can pitch its help at
your level.

Two: try first, then ask. Do the thinking before the machine does. This
is what the tutor version in the maths study enforced.

Three: ask the AI to quiz you, not to explain again. Testing yourself
beats rereading, and a chatbot is a tireless quiz-maker.

Four: explain it back in your own words and ask what you got wrong.

Five: come back to it later in the week. Spacing beats cramming.

Six: write down what you caught, including the AI’s mistakes. Remember
that your feeling of understanding is not a reliable gauge, so you need
a record.

\[Click\] This is what we call “Learn it with AI”: two to four hours a
week using AI to teach yourself something you care about. It is the main
hands-on work of the course, and the Thursday journal is where you
record what you caught.

</div>

## <span class="year">Part 2</span> How the four weeks work

<span class="lede">October 12 to November 6. Ungraded, on Zoom, and more
on the calendar than anyone needs.</span>

## Week 1: live every morning

<div class="bigtable xl">

| Day | Session (Mountain time) |
|----|----|
| **Monday, October 12** | 10 a.m., recorded. Welcome: how the course works, and how you learn (today) |
| **Tuesday, October 13** | 10 a.m., recorded. A short history of AI |
| **Wednesday, October 14** | 10 a.m., recorded. What AI is: from AI to machine learning to large language models |
| **Thursday, October 15** | 10 a.m., recorded. **Hands-on: centaur or cyborg, live.** Bring your ChatGPT Edu account. Office hours at 11, not recorded |
| **Friday, October 16** | **Small groups** meet for the first time, in the slot you signed up for. Not recorded |

</div>

## Weeks 2 to 4: a week in the course

<div class="bigtable">

| When | What | Expected? |
|----|----|----|
| Monday, 10 a.m. | **“How I used AI this week”**, then a talk on the week’s topic | Your choice |
| Wednesday, 10 a.m. | A second talk, sometimes by a guest | Your choice |
| Wednesday, 2 p.m. | **Watch and do**, 90 minutes: try it live, together | Optional |
| Through the week | **Guest talks** from clinicians and researchers | Your choice |
| On your own | **Learn it with AI**, 2 to 4 hours | Yes |
| Thursday, 11 a.m. | Office hours, drop in, not recorded | Optional |
| Thursday night | **Learning journal** entry | Yes |
| Friday | **Small group**, in your slot, not recorded | Best effort |

</div>

**Aim for about 3 hours a week of sessions**, live or recorded, chosen
by interest. Plan on 8 to 10 hours a week in total.

## The talks: a starting plan

<div class="columns">

<div class="column" width="33%">

<div class="panel">

<span class="ptitle">Week 2 · getting good at it</span>

**Mon** Getting good answers: how a chatbot reads your prompt

**Wed** Professional work with AI: writing and beyond, with **Christina
Olson**[^1]

</div>

</div>

<div class="column" width="34%">

<div class="panel">

<span class="ptitle">Week 3 · AI and your patients</span>

**Mon** Talking with patients about AI

**Wed** To be announced: bias and equity, or building a small tool live

</div>

</div>

<div class="column" width="33%">

<div class="panel">

<span class="ptitle">Week 4 · responsibility</span>

**Mon** Who answers for the note: ethics and liability

**Wed** Where this is going, for jobs and the planet, and what you will
keep

</div>

</div>

</div>

Topics may change. **Canvas has the current plan.**

## Guest talks and workshops

<div class="bigtable">

| Date | Who | Topic |
|----|----|----|
| Wednesday, October 21, 1 p.m. | Dan Denman | AI in neuroscience |
| Thursday, October 22, 1 p.m. | Matt Zuckerman[^2] | AI in medical education |
| Tuesday, October 27, 10 a.m. to noon | Christina Olson | Workshop, with breakout rooms |
| Tuesday, October 27, 1 p.m. | Matt DeCamp | Ethics |
| Thursday, October 29, 1 p.m. | Mike Rosenberg | Cardiology |
| Monday, November 2, 11 a.m. | Elizabeth Kudron | Pediatrics |
| Monday, November 2, 1 p.m. | Sorabh Singhal | Psychiatry |

</div>

**Attend or watch one guest talk a week.** All are on Zoom and recorded.
Times are Mountain time; the calendar in Canvas is the official list.

## What we ask of you

<div class="columns">

<div class="column" width="50%">

- The course is **ungraded**
- **Learning journal**, Thursday nights in Canvas: complete or
  incomplete, with a one-line reply in weeks 1 and 2
- **Week 4 piece**: “what you will keep”, five minutes at your Friday
  group on November 6
- Missing a session? Use the school’s process for **absences**. You do
  not need to ask me

</div>

<div class="column center-v" width="50%">

> The most important evaluation is your own. Did you use the gift of
> four weeks well?

</div>

</div>

**Due dates:** journals on October 15, 22, and 29; the week 4 piece on
November 5.

## Four rules for every AI tool in this course

<div class="columns">

<div class="column" width="25%">

<div class="panel">

<span class="ptitle">1 · Use CU tools</span>

Your university **ChatGPT Edu** or **Copilot** account

</div>

</div>

<div class="column" width="25%">

<div class="panel warm">

<span class="ptitle">2 · No real patients</span>

**Never** put real patient information into a course activity. Make
cases up

</div>

</div>

<div class="column" width="25%">

<div class="panel">

<span class="ptitle">3 · Check it</span>

Check what matters **before** you rely on it

</div>

</div>

<div class="column" width="25%">

<div class="panel">

<span class="ptitle">4 · You sign the note</span>

Whatever AI wrote, **you** are responsible for it

</div>

</div>

</div>

<div style="margin-top: 1.2em;">

**No ChatGPT Edu account yet?** Finish CU’s **Student AI Training** in
Canvas first. The invitation comes to your university email. Do it
**before Thursday**.

</div>

## Where things are

<div class="columns">

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">Canvas: the official record</span>

- **Announcements** and the **calendar**, with Zoom links
- Weekly **modules** and the **journal**
- **General Questions** discussion
- Recordings of the talks

</div>

</div>

<div class="column" width="50%">

<div class="panel">

<span class="ptitle">Discord: an unofficial experiment</span>

- A place to share what you tried, ask quick questions, and post
  resources
- Made-up cases only, like everywhere else

<div class="columns">

<div class="column" width="55%">

Join: [discord.gg/KrEX8H6ad](https://discord.gg/KrEX8H6ad)

</div>

<div class="column center-col" width="45%">

<img src="images/discord-qr.svg" class="card"
data-fig-alt="QR code linking to the course Discord invitation, discord.gg/KrEX8H6ad."
height="200" />

</div>

</div>

</div>

</div>

</div>

## How we treat each other

- We explore **different views** with respect. AI in medicine is
  contested, and reasonable people disagree
- Disagree with the **idea**, with care for the **person**
- On Zoom, in Discord, and online, your words are part of the course
- If something makes the course feel unsafe, contact me or the School of
  Medicine

## An apology, and an invitation

<span class="lede">AI in medicine changes every month, and I have my own
blind spots.</span>

**If something is not in the course, do not assume it is unimportant.**
Tell me what you want to learn, and I will adapt where I can.

## The course book

<div class="columns">

<div class="column" width="64%">

[<img src="images/aim-book.jpg" class="card"
data-fig-alt="Screenshot of the course book home page, AI in Medicine, with a sidebar listing the syllabus, Learn it with AI, the weekly learning journal, Friday small groups, and chapters grouped by week." />](https://aim.seandavis.net)

</div>

<div class="column center-col" width="36%">

<span class="lede">**[aim.seandavis.net](https://aim.seandavis.net)**</span>

<img src="images/aim-book-qr.svg" class="card"
data-fig-alt="QR code linking to the course book at aim.seandavis.net."
height="220" />

The syllabus, the weekly routine, and a chapter for each topic, each
with something to **do**

</div>

</div>

## This week

1.  **Get your ChatGPT Edu account** working, before Thursday
2.  **Sign up for a Friday small-group slot** in Canvas
3.  Come to, or watch, **Tuesday and Wednesday**
4.  **Thursday**: hands-on, then office hours, then your first
    **journal** entry that night

## What remains

> Education is that which remains, if one has forgotten everything he
> learned in school.
>
> <span class="attrib">Albert Einstein, 1936, quoting “a wit”. The
> saying was already decades old; B. F. Skinner wrote his own version in
> 1964.</span>

<div class="aside">

Sources: ([Quote Investigator, 2014](#ref-qi2014forgotten)); ([Skinner,
1964](#ref-skinner1964)).

</div>

## Questions

<div class="columns">

<div class="column" width="62%">

<span class="lede">Canvas: General Questions</span>

<span class="lede">Office hours: Thursday, 11 a.m.</span>

<span class="lede">Discord:
[discord.gg/KrEX8H6ad](https://discord.gg/KrEX8H6ad)</span>

</div>

<div class="column center-col" width="38%">

<img src="images/discord-qr.svg" class="card"
data-fig-alt="QR code linking to the course Discord invitation, discord.gg/KrEX8H6ad."
height="300" />

</div>

</div>

## References

<div id="refs" class="references csl-bib-body hanging-indent"
data-entry-spacing="0" data-line-spacing="2">

<div id="ref-pmid:40560616" class="csl-entry">

Bastani, H., Bastani, O., Sungu, A., Ge, H., Kabakcı, Ö., & Mariman, R.
(2025). Generative AI without guardrails can harm learning: Evidence
from high school mathematics. *Proceedings of the National Academy of
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[^1]: Christina Olson: course co-director; pediatric hospitalist and
    Telehealth Medical Director, Children’s Colorado.

[^2]: Matt Zuckerman: course co-director; emergency medicine.
